منابع مشابه
Drug Metabolitesand Immunoassays
Many drugs are converted to metabolites to varying degrees, and these metabolites may or may not be bioac-tive. The degree of bioactivity is not always clearly known. Blood often contains a mixture of parent drug and metab-olites, with the concentrations of the metabolites often not being very predictable. The parent drug occasionally requires biotransformation before it becomes bioactive. The ...
متن کاملDetection of methadone, LAAM, and their metabolites by methadone immunoassays.
l-Alpha-acetylmethadol (LAAM) was recently approved as a substitute for methadone. LAAM, methadone, and their common metabolite, methadol, are extensively N-demethylated. The structural similarities of LAAM and its metabolites to methadone suggest that they may cross-react in methadone immunoassays. To test this hypothesis, drug-free urine was fortified with LAAM, norLAAM, dinorLAAM, methadol, ...
متن کاملAssessment of drug metabolites.
The guidance for safety testing of drug metabolites ¤MIST¥ from the FDA ¤2008¥1¥ and the ICH ¤2009¥2¥ has had significant impact on drug discovery and development. Before the MIST guidance, there were no regulations for drug metabolites. Nonclinical evaluation of drug safety is assessed by comparison between systemic exposure in nonclinical studies and in human studies; therefore, the nonclinic...
متن کاملEvaluation of immunoassays for semiquantitative detection of cocaine and metabolites or heroin and metabolites in extracts of sweat patches.
Two types of immunoassays, radioimmunoassay (RIA) and microplate enzyme immunoassay (EIA), were compared for their ability to detect and quantitate cocaine and metabolites or heroin and metabolites in extracts of sweat patches. Experiments used sweat patches that had been fortified with cocaine, benzoylecgonine (BE), and ecgonine methyl ester (EME) or 6-acetylmorphine (6-AM), heroin, and morphi...
متن کاملPharmacologically active drug metabolites: impact on drug discovery and pharmacotherapy.
Metabolism represents the most prevalent mechanism for drug clearance. Many drugs are converted to metabolites that can retain the intrinsic affinity of the parent drug for the pharmacological target. Drug metabolism redox reactions such as heteroatom dealkylations, hydroxylations, heteroatom oxygenations, reductions, and dehydrogenations can yield active metabolites, and in rare cases even con...
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ژورنال
عنوان ژورنال: Clinical Chemistry
سال: 1994
ISSN: 0009-9147,1530-8561
DOI: 10.1093/clinchem/40.10.1863